Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013297 | 0.88 | GAA (0.48) | KDM4EALDH1A1GAALMNARBP4 | |
| SCHEMBL2096558 | 0.84 | KCNN4 (0.41) | KDM4EKCNN4HTR6 | |
| SCHEMBL27665953 | 0.83 | KDM4E (0.52) | KDM4EALDH1A1GAALMNARBP4 | |
| SCHEMBL2095145 | 0.77 | TP53 (0.46) | KDM4EALDH1A1GAA | |
| SCHEMBL27644470 | 0.76 | DRD2 (0.43) | KDM4EALDH1A1GAALMNARBP4 | |
| SCHEMBL5013426 | 0.74 | RBP4 (0.40) | KDM4EALDH1A1GAALMNARBP4 | |
| SCHEMBL5015053 | 0.72 | SIGMAR1 (0.49) | POLBDRD2SIGMAR1 | |
| SCHEMBL8169598 | 0.72 | KDM4E (0.59) | KDM4EALDH1A1GAALMNAPOLB | |
| SCHEMBL5541635 | 0.71 | KDM4E (0.62) | KDM4EALDH1A1GAALMNAPOLB | |
| SCHEMBL6863328 | 0.71 | KDM4E (0.62) | KDM4EALDH1A1GAALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |