Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8169555 | 0.90 | CASP1 (0.49) | KDM4EALDH1A1GAALMNAFAAH | |
| SCHEMBL8168480 | 0.86 | SIGMAR1 (0.54) | KDM4EALDH1A1LMNAFAAHSIGMAR1 | |
| SCHEMBL6863328 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1GAALMNAFAAH | |
| SCHEMBL6863480 | 0.83 | SIGMAR1 (0.67) | KDM4EALDH1A1GAALMNAFAAH | |
| SCHEMBL8311608 | 0.82 | MAPT (0.62) | ALDH1A1SIGMAR1KMT2AMEN1HTT | |
| SCHEMBL8173934 | 0.81 | SIGMAR1 (0.70) | KDM4EALDH1A1GAAFAAHTSHR | |
| SCHEMBL8172252 | 0.81 | POLB (0.64) | KDM4EFAAHPOLBKMT2AMEN1 | |
| SCHEMBL8173670 | 0.81 | ALDH1A1 (0.57) | KDM4EALDH1A1LMNAFAAHHTT | |
| SCHEMBL11091530 | 0.80 | MAPT (0.59) | ALDH1A1LMNATSHRSIGMAR1KMT2A | |
| SCHEMBL6862996 | 0.79 | KDM4E (0.74) | KDM4EALDH1A1GAALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000516629-A | — | — | 2000-12-12 | — | — | JP | claimed |
| EP-0929537-A1 | TROPONYL PIPERAZINES AS SELECTIVE DOPAMINE D4 RECEPTOR LIGANDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-21 | — | — | EP | claimed |
| WO-1998007711-A1 | TROPONYL PIPERAZINES AS SELECTIVE DOPAMINE D4 RECEPTOR LIGANDS | HOECHST MARION ROUSSEL, INC. (US) | 1998-02-26 | — | — | WO | claimed |
| US-5998414-A | PSYCHOLOGICAL DISORDERS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0929537-A1 | TROPONYL PIPERAZINES AS SELECTIVE DOPAMINE D4 RECEPTOR LIGANDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998007711-A1 | TROPONYL PIPERAZINES AS SELECTIVE DOPAMINE D4 RECEPTOR LIGANDS | HOECHST MARION ROUSSEL, INC. (US) | 1998-02-26 | — | — | WO | disclosed |