Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.38 |
| ▸ | USP2 | O75604 | 6/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012930 | 0.82 | CNR2 (0.38) | CNR2CNR1CYP3A4USP2CYP2D6 | |
| SCHEMBL5016264 | 0.76 | HPGD (0.38) | CNR2CNR1CYP3A4USP2CYP2D6 | |
| SCHEMBL1087047 | 0.73 | CYP3A4 (0.48) | POLBCYP3A4USP2CYP2D6ALDH1A1 | |
| SCHEMBL5170031 | 0.71 | MAPK14 (0.49) | POLBALDH1A1MAPK1LMNA | |
| SCHEMBL5011733 | 0.68 | EPHX2 (0.39) | CYP3A4ALDH1A1CYP2C9TSHRHPGD | |
| SCHEMBL5013591 | 0.67 | TSHR (0.47) | POLBCYP3A4USP2CYP2D6ALDH1A1 | |
| SCHEMBL5012907 | 0.65 | TSHR (0.46) | ALDH1A1TSHRHPGDSMN1; SMN2LMNA | |
| SCHEMBL5012929 | 0.63 | HPGD (0.40) | CNR2CNR1HPGDLMNAHTT | |
| SCHEMBL3568071 | 0.62 | MAPT (0.47) | ALDH1A1HPGDLMNAHTT | |
| SCHEMBL3077014 | 0.61 | GRM2 (0.52) | CYP3A4USP2CYP2D6ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |