Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013516 | 0.89 | RAB9A (0.46) | RAB9AKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL5012911 | 0.80 | PPARG (0.36) | PPARGPPARAKMT2AALDH1A1HPGD | |
| SCHEMBL4258712 | 0.80 | PPARG (0.38) | RAB9APPARGPPARAKMT2AALDH1A1 | |
| SCHEMBL5011711 | 0.72 | MAPT (0.46) | KMT2AALDH1A1MEN1HTTMAPT | |
| SCHEMBL4262167 | 0.68 | MAPT (0.43) | RAB9AKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL4269518 | 0.66 | ALDH1A1 (0.41) | RAB9AKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL5011733 | 0.66 | EPHX2 (0.39) | KMT2AALDH1A1HPGDMEN1SMN1; SMN2 | |
| SCHEMBL1449040 | 0.63 | MAPT (0.58) | RAB9AKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL10889357 | 0.62 | KMT2A (0.65) | RAB9AKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL12708550 | 0.62 | ALDH1A1 (0.50) | RAB9AKMT2AALDH1A1MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |