Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013432 | 0.89 | RAB9A (0.40) | RAB9AKMT2AMEN1ALOX12MAPT | |
| SCHEMBL4262167 | 0.77 | MAPT (0.43) | RAB9AKMT2AMEN1ALOX12MAPT | |
| SCHEMBL5012907 | 0.74 | TSHR (0.46) | ALDH1A1HPGDLMNASMN1; SMN2NPSR1 | |
| SCHEMBL5011597 | 0.73 | PLAAT3 (0.41) | RAB9AKMT2AMAPTALDH1A1POLB | |
| SCHEMBL10889357 | 0.66 | KMT2A (0.65) | RAB9AKMT2AMEN1ALOX12MAPT | |
| SCHEMBL11086969 | 0.66 | ALDH1A1 (0.74) | RAB9AKMT2AMEN1ALOX12MAPT | |
| SCHEMBL31650343 | 0.63 | MAPT (0.78) | RAB9AKMT2AMEN1ALOX12MAPT | |
| SCHEMBL2205660 | 0.63 | RAB9A (0.98) | RAB9AKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL12325527 | 0.62 | KMT2A (0.63) | RAB9AKMT2AMEN1ALOX12MAPT | |
| SCHEMBL1697905 | 0.62 | RAB9A (0.61) | RAB9AKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |