Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1086445 | 0.75 | P2RX7 (0.40) | P2RX7AURKAAURKB | |
| SCHEMBL5012881 | 0.73 | KDM4E (0.37) | FAAHMMP13 | |
| SCHEMBL5011798 | 0.71 | TSHR (0.41) | OPRL1CCR3CYP2D6 | |
| SCHEMBL5012778 | 0.65 | TP53 (0.37) | — | |
| SCHEMBL5015150 | 0.65 | MAPT (0.53) | — | |
| SCHEMBL1086756 | 0.64 | CCR3 (0.42) | OPRL1CCR3MMP13 | |
| SCHEMBL5013547 | 0.61 | POLB (0.39) | FAAHCYP2D6 | |
| SCHEMBL1086201 | 0.61 | P2RX7 (0.40) | P2RX7AURKAAURKB | |
| SCHEMBL23793444 | 0.59 | HPGD (0.73) | P2RX7 | |
| SCHEMBL9693738 | 0.56 | KAT6A (0.47) | KAT6AP2RX7BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |