SCHEMBL5011798

SCHEMBL5011798

O=C(NCc1ccc(Cl)c(Cl)c1)ON1N(Cc2ccc3ccccc3c2)C(=O)OC12CCCCC2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
SSTR3 P32745 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TRPV1 Q8NER1 3/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CCR3 P51677 1/20 0.38
OPRL1 P41146 1/20 0.36
TAOK1 Q7L7X3 1/20 0.35
TAOK3 Q9H2K8 1/20 0.35
ESR1 P03372 1/20 0.35
NR3C1 P04150 1/20 0.35
PGR P06401 1/20 0.35
NR3C2 P08235 1/20 0.35
ESR2 Q92731 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CYP3A4 P08684 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5012907 0.88 TSHR (0.46) TSHRSMN1; SMN2ALDH1A1LMNAHTT
SCHEMBL4259750 0.76 TSHR (0.40) TSHRSSTR3SMN1; SMN2TRPV1ALDH1A1
SCHEMBL1086552 0.70 HRH3 (0.46) SMN1; SMN2TRPV1LMNAHTTCCR3
SCHEMBL5011684 0.69 LMNA (0.47) SMN1; SMN2TRPV1ALDH1A1LMNAHTT
SCHEMBL5012881 0.67 KDM4E (0.37) ALDH1A1LMNAMEN1KMT2A
SCHEMBL2867648 0.65 ERCC1 (0.71) TSHRSSTR3SMN1; SMN2TRPV1ALDH1A1
SCHEMBL29194232 0.65 TSHR (0.61) TSHRSMN1; SMN2ALDH1A1MEN1KMT2A
SCHEMBL4271658 0.64 TSHR (0.39) TSHRSMN1; SMN2ALDH1A1TAOK1TAOK3
SCHEMBL4272713 0.63 TSHR (0.45) TSHRSMN1; SMN2ALDH1A1ESR1NR3C1
SCHEMBL3282688 0.63 TSHR (0.68) TSHRSMN1; SMN2TRPV1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP claimed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO claimed
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP disclosed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO disclosed