SCHEMBL5013925 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	STAT3	P40763	1/20	0.71

▸	STAT1	P42224	1/20	0.71

▸	TOP1	P11387	4/20	0.41

▸	CYCS	P99999	3/20	0.40

▸	DHODH	Q02127	1/20	0.38

▸	ENPP2	Q13822	1/20	0.36

▸	TERT	O14746	2/20	0.36

▸	ABCG2	Q9UNQ0	1/20	0.35

▸	MAPK10	P53779	1/20	0.35

▸	MAPK14	Q16539	1/20	0.35

▸	LRRK2	Q5S007	1/20	0.34

▸	ALDH1A1	P00352	2/20	0.33

▸	HSD17B10	Q99714	2/20	0.33

▸	CYP3A4	P08684	1/20	0.33

▸	HPGD	P15428	1/20	0.33

▸	AXL	P30530	1/20	0.33

▸	ALOX15	P16050	1/20	0.33

▸	TSHR	P16473	1/20	0.33

▸	ALOX12	P18054	1/20	0.33

▸	PTGS1	P23219	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2563180	0.88	STAT3 (0.91)	STAT3STAT1TOP1CYCSENPP2
SCHEMBL5013193	0.87	STAT3 (0.67)	STAT3STAT1TOP1CYCSENPP2
SCHEMBL30608144	0.86	STAT3 (0.89)	STAT3STAT1TOP1CYCSENPP2
Zinc Ion SCHEMBL30574155	0.86	STAT3 (0.89)	STAT3STAT1TOP1CYCSENPP2
SCHEMBL29459724	0.86	STAT3 (0.89)	STAT3STAT1TOP1CYCSENPP2
SCHEMBL31127547	0.86	STAT3 (0.89)	STAT3STAT1TOP1CYCSENPP2
SCHEMBL28908470	0.86	STAT3 (0.89)	STAT3STAT1TOP1CYCSENPP2
SCHEMBL31127545	0.86	STAT3 (0.89)	STAT3STAT1TOP1CYCSENPP2
SCHEMBL30574152	0.86	STAT3 (0.89)	STAT3STAT1TOP1CYCSENPP2
SCHEMBL26073065	0.86	STAT3 (0.89)	STAT3STAT1TOP1CYCSENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7417142-B2	Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same	THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, INC. (US)	2008-08-26	—	—	US	disclosed
US-20060030718-A1	Cobalt-based catalysts for the cyclization of alkenes	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION	2006-02-09	—	—	US	disclosed
US-6951935-B2	Heteroatom-substituted porphyrins and methods for synthesis of same	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US)	2005-10-04	—	—	US	disclosed
US-20050124596-A1	Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same	UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION	2005-06-09	—	—	US	disclosed
US-20030236400-A1	Heteroatom-substituted porphyrins and methods for synthesis of same	UNIVERSITY OF TENNESSEE RESEARCH CORPORATION	2003-12-25	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20060030718-A1	Cobalt-based catalysts for the cyclization of alkenes	PPOX, HCCS, ICOSLG	STAT3 3817/4885STAT1 4312/4885TOP1 1268/4885
US-20030236400-A1	Heteroatom-substituted porphyrins and methods for synthesis of same	PPOX, HMBS, UROD	STAT3 4156/4885STAT1 3973/4885TOP1 3026/4885
US-20050124596-A1	Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same	PPOX, PPIF, HMBS	STAT3 2986/4885STAT1 3579/4885TOP1 1564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.