SCHEMBL5014366

SCHEMBL5014366

CC1CN(c2c(CO)cc(-c3nnc(-c4ccccc4)s3)c(F)c2F)CC(C)O1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.43
KDM4E B2RXH2 4/20 0.43
HPGD P15428 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
L3MBTL1 Q9Y468 3/20 0.40
LMNA P02545 2/20 0.40
ATM Q13315 1/20 0.40
RAB9A P51151 1/20 0.37
TSHR P16473 2/20 0.36
MAPK1 P28482 1/20 0.36
HSD17B10 Q99714 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HTT P42858 2/20 0.36
OPRK1 P41145 1/20 0.36
PIK3R1 P27986 2/20 0.36
PIK3CA P42336 2/20 0.36
ADORA2A P29274 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5015619 0.91 HRH3 (0.37) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5014390 0.88 ALDH1A1 (0.41) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5012713 0.85 PIK3R1 (0.35) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5012716 0.84 PIK3R1 (0.34) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5133875 0.84 PIK3R1 (0.34) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5014333 0.83 PIK3R1 (0.36) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5015657 0.83 PIK3R1 (0.34) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5012742 0.83 PIK3R1 (0.34) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5012837 0.82 ALDH1A1 (0.38) ALDH1A1KDM4EHPGDNPSR1TDP1
SCHEMBL5014391 0.82 ALDH1A1 (0.41) ALDH1A1KDM4EHPGDNPSR1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1888597-A2 ANTIBACTERIAL AGENTS Warner-Lambert Company LLC (US) 2008-02-20 EP disclosed
WO-2006120563-A2 ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY LLC (US) 2006-11-16 WO disclosed