Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 6/20 | 0.42 |
| ▸ | BCHE | P06276 | 5/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31163069 | 0.81 | POLB (0.42) | CACNA1CHTR2CSLC6A4CACNA1GCACNA1B | |
| SCHEMBL20054017 | 0.81 | POLB (0.42) | CACNA1CHTR2CSLC6A4CACNA1GCACNA1B | |
| SCHEMBL16980506 | 0.80 | MEN1 (0.46) | HTR2CSLC6A4LMNA | |
| SCHEMBL30264826 | 0.80 | HSP90AA1 (0.47) | ACHEBCHEHTR2CSLC6A4GLS | |
| SCHEMBL5017051 | 0.80 | HTR2C (0.38) | CACNA1CHTR2CSLC6A4CACNA1GCACNA1B | |
| SCHEMBL14036624 | 0.77 | CACNA1G (0.39) | CACNA1CHTR2CSLC6A4CACNA1GCACNA1B | |
| SCHEMBL5013658 | 0.77 | CACNA1G (0.36) | CACNA1CHTR2CSLC6A4CACNA1GCACNA1B | |
| SCHEMBL14036620 | 0.77 | KCNA5 (0.45) | ACHEBCHE | |
| SCHEMBL8017533 | 0.76 | HTR2C (0.47) | CACNA1CHTR2CSLC6A4CACNA1GCACNA1B | |
| SCHEMBL25211795 | 0.74 | PYCR1 (0.46) | CACNA1CHTR2CSLC6A4CACNA1GCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |