Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015064 | 0.91 | KCNA5 (0.46) | KCNA5KDM4AKDM4ELMNAAAK1 | |
| SCHEMBL14036620 | 0.76 | KCNA5 (0.45) | KCNA5KDM4ATRPV1 | |
| SCHEMBL5739222 | 0.76 | ALDH1A1 (0.40) | KCNA5KDM4AKDM4ELMNAAAK1 | |
| SCHEMBL14036623 | 0.76 | KDM4A (0.44) | KCNA5KDM4AKDM4ELMNAMAPT | |
| SCHEMBL27723354 | 0.75 | KCNA5 (0.39) | KCNA5KDM4AKDM4ELMNAAAK1 | |
| SCHEMBL5460255 | 0.75 | EPHX2 (0.42) | KCNA5KDM4AKDM4ELMNAMAPT | |
| SCHEMBL18676832 | 0.74 | KCNA5 (0.43) | KCNA5KDM4AKDM4ELMNACACNA1H | |
| SCHEMBL5015048 | 0.73 | SLC6A4 (0.36) | — | |
| SCHEMBL12743180 | 0.73 | KCNA5 (0.55) | KCNA5KDM4AMAPTRPS6KA1TP53 | |
| SCHEMBL13761066 | 0.73 | KDM4A (0.45) | KCNA5KDM4AKDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |