Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.49 |
| ▸ | GPR88 | Q9GZN0 | 10/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910550 | 0.84 | FAAH (0.47) | FAAHGPR88SMN1; SMN2MAPK1 | |
| SCHEMBL4435918 | 0.80 | ALOX5 (0.53) | ALDH1A1 | |
| SCHEMBL1444160 | 0.79 | GPR88 (0.70) | FAAHGPR88SMN1; SMN2MAPK1 | |
| SCHEMBL574487 | 0.76 | TACR3 (0.51) | GPR88ALDH1A1 | |
| SCHEMBL2520989 | 0.74 | GPR88 (0.75) | GPR88 | |
| SCHEMBL1553718 | 0.74 | GPR88 (0.75) | GPR88 | |
| SCHEMBL13560366 | 0.73 | GPR88 (0.60) | GPR88 | |
| SCHEMBL8463046 | 0.72 | AKR1C3 (0.51) | GPR88MAPK1 | |
| SCHEMBL15902279 | 0.70 | TP53 (0.59) | GPR88SMN1; SMN2MAPK1 | |
| SCHEMBL10323207 | 0.70 | HRH1 (0.50) | SMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922073-A1 | NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | Parion Sciences, Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007018640-A1 | NEW CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2007-02-15 | — | — | WO | disclosed |