Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ACACB | O00763 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20425198 | 0.85 | PRKCA (0.54) | ACACBMAOB | |
| SCHEMBL20915059 | 0.82 | ALOX5 (0.48) | ALOX5LMNAL3MBTL1ACACBHDAC3 | |
| SCHEMBL574487 | 0.81 | TACR3 (0.51) | LMNAALDH1A1 | |
| SCHEMBL5015635 | 0.80 | FAAH (0.49) | ALDH1A1 | |
| SCHEMBL8691785 | 0.79 | MMP13 (0.50) | ACACB | |
| SCHEMBL8691786 | 0.79 | MMP13 (0.50) | ACACB | |
| SCHEMBL19329926 | 0.78 | HDAC3 (0.53) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL20425136 | 0.77 | LMNA (0.56) | ALOX5LMNAL3MBTL1ACACBMAOB | |
| SCHEMBL5273185 | 0.77 | BCHE (0.60) | L3MBTL1 | |
| SCHEMBL28857417 | 0.76 | ALOX5 (0.53) | ALOX5LMNAL3MBTL1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761480-B1 | MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | EP | claimed |
| EP-1761480-B1 | MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | EP | disclosed |