Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012256 | 0.91 | TP53 (0.46) | ALDH1A1MAPTMEN1KMT2ATP53 | |
| SCHEMBL5012836 | 0.86 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5014558 | 0.80 | LMNA (0.38) | SMN1; SMN2MAPTMEN1KMT2ATP53 | |
| SCHEMBL16175732 | 0.74 | KMT2A (0.49) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5124256 | 0.68 | KMT2A (0.51) | SMN1; SMN2ALDH1A1MAPTKMT2ACYP1A2 | |
| SCHEMBL16562183 | 0.67 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16175753 | 0.66 | MCHR1 (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL11767205 | 0.65 | NPC1 (0.64) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16175620 | 0.64 | KMT2A (0.47) | ALDH1A1MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL16175419 | 0.64 | KMT2A (0.47) | ALDH1A1MEN1KMT2ATP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |