Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012256 | 0.89 | TP53 (0.46) | LMNATP53MAPTRAB9AMEN1 | |
| SCHEMBL5010991 | 0.78 | TRPV1 (0.41) | LMNATP53MAPTCYP2C19CYP3A4 | |
| SCHEMBL5014395 | 0.76 | RAB9A (0.43) | TP53MAPTRAB9AMEN1KMT2A | |
| SCHEMBL5012836 | 0.76 | ALDH1A1 (0.49) | LMNATP53MAPTCYP2C19CYP3A4 | |
| SCHEMBL16175761 | 0.74 | KMT2A (0.48) | LMNATP53MAPTCYP2C19KIT | |
| SCHEMBL5048772 | 0.68 | P2RY12 (0.41) | TP53 | |
| SCHEMBL5120110 | 0.67 | KMT2A (0.49) | MAPTRAB9AHPGDEPHX2MEN1 | |
| SCHEMBL5012898 | 0.66 | KMT2A (0.46) | LMNAMAPTCYP3A4RAB9AEPHX2 | |
| SCHEMBL16175692 | 0.66 | KMT2A (0.50) | TP53HPGDMEN1KMT2A | |
| SCHEMBL10256979 | 0.64 | EPHX2 (0.63) | LMNACYP2C19RAB9AEPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |