Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014558 | 0.89 | LMNA (0.38) | TP53LMNANPC1RAB9AMEN1 | |
| SCHEMBL5012836 | 0.77 | ALDH1A1 (0.49) | TP53LMNANPC1RAB9ATHRB | |
| SCHEMBL5010991 | 0.74 | TRPV1 (0.41) | TP53LMNANPC1RAB9ATHRB | |
| SCHEMBL16175419 | 0.73 | KMT2A (0.47) | TP53LMNANPC1RAB9AGLA | |
| SCHEMBL5048772 | 0.72 | P2RY12 (0.41) | TP53 | |
| SCHEMBL16175692 | 0.67 | KMT2A (0.50) | TP53GLAMEN1KMT2AALDH1A1 | |
| SCHEMBL5012907 | 0.65 | TSHR (0.46) | LMNATHRBALDH1A1CHRM1TSHR | |
| SCHEMBL5123358 | 0.65 | KMT2A (0.49) | TP53LMNANPC1RAB9AGLA | |
| SCHEMBL16175732 | 0.64 | KMT2A (0.49) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2096445 | 0.63 | SMN1; SMN2 (0.64) | LMNANPC1RAB9ATHRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |