SCHEMBL5016359

SCHEMBL5016359

O=C(NCCc1ccccc1)ON1N(Cc2ccccc2C(F)(F)F)C(=O)OC12CCCCC2

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
KDM4E B2RXH2 3/20 0.38
LMNA P02545 2/20 0.38
HPGD P15428 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2C19 P33261 1/20 0.37
POLB P06746 2/20 0.37
EPHX2 P34913 2/20 0.37
GAA P10253 1/20 0.36
ATM Q13315 2/20 0.36
P2RX7 Q99572 4/20 0.36
TSHR P16473 1/20 0.36
SCD O00767 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5011597 0.82 PLAAT3 (0.41) ALDH1A1KDM4ELMNACYP3A4CYP2C19
SCHEMBL5015097 0.77 ALDH1A1 (0.42) ALDH1A1KDM4ELMNAHPGDTDP1
SCHEMBL4272821 0.76 TACR2 (0.40) ALDH1A1KDM4ELMNAHPGDTDP1
SCHEMBL5011711 0.75 MAPT (0.46) ALDH1A1LMNACYP3A4CYP2C19GAA
SCHEMBL1086526 0.69 EPHX2 (0.45) ALDH1A1KDM4ELMNAHPGDTDP1
SCHEMBL5015147 0.67 KMT2A (0.37) ALDH1A1KDM4EPOLBEPHX2ATM
SCHEMBL5067054 0.67 KDM4E (0.36) ALDH1A1KDM4ETDP1POLBEPHX2
SCHEMBL5012942 0.64 EPHX2 (0.37) ALDH1A1KDM4ETDP1EPHX2GAA
SCHEMBL10402732 0.64 NPC1 (0.49) KDM4ELMNACYP3A4CYP2C19GAA
SCHEMBL28146060 0.62 GAA (0.55) ALDH1A1KDM4ECYP3A4CYP2C19POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP claimed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO claimed
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP disclosed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO disclosed