SCHEMBL5015097

SCHEMBL5015097

COc1cccc(NC(=O)ON2N(Cc3ccccc3C(F)(F)F)C(=O)OC23CCCCC3)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.42
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
LMNA P02545 3/20 0.42
KDM4E B2RXH2 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MAPT P10636 3/20 0.40
GAA P10253 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
TP53 P04637 1/20 0.40
HSD17B10 Q99714 1/20 0.40
RAB9A P51151 2/20 0.40
PKM P14618 1/20 0.40
MAPK1 P28482 1/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.40
KCNH2 Q12809 2/20 0.39
ALOX15 P16050 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4258527 0.78 MEN1 (0.42) ALDH1A1MEN1KMT2ALMNAKDM4E
SCHEMBL5016359 0.77 ALDH1A1 (0.38) ALDH1A1MEN1KMT2ALMNAKDM4E
SCHEMBL5011684 0.76 LMNA (0.47) ALDH1A1LMNAMAPTGAASMN1; SMN2
SCHEMBL5013591 0.69 TSHR (0.47) ALDH1A1MEN1KMT2ALMNAKDM4E
SCHEMBL5012818 0.65 MAPT (0.49) ALDH1A1LMNANPSR1MAPTGAA
SCHEMBL4271025 0.64 TRPV1 (0.46) ALDH1A1LMNAKDM4EGAASMN1; SMN2
SCHEMBL11204897 0.64 NPC1 (0.70) KMT2AKDM4EGAASMN1; SMN2TP53
SCHEMBL5012942 0.63 EPHX2 (0.37) ALDH1A1MEN1KMT2AKDM4EMAPT
SCHEMBL28612397 0.62 MAOB (0.51) LMNAHPGDPOLB
SCHEMBL1166738 0.61 ALDH1A1 (0.58) ALDH1A1KMT2AGAASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP claimed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO claimed
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP disclosed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO disclosed