SCHEMBL5015147

SCHEMBL5015147

O=C1OC2(CCCCC2)N(C(=O)c2cc(C(F)(F)F)ccc2Cl)N1Cc1ccccc1C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.37
EPHX2 P34913 2/20 0.36
KCNH2 Q12809 1/20 0.35
MAPK8 P45983 1/20 0.35
MAPK10 P53779 1/20 0.35
CRHR1 P34998 6/20 0.35
MAPT P10636 2/20 0.35
THRB P10828 1/20 0.35
CRHR2 Q13324 1/20 0.35
ALDH1A1 P00352 2/20 0.35
TSHR P16473 2/20 0.35
MEN1 O00255 1/20 0.35
ATM Q13315 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
KDM4E B2RXH2 1/20 0.34
SIRT2 Q8IXJ6 1/20 0.34
SIRT1 Q96EB6 1/20 0.34
TP53 P04637 1/20 0.34
POLB P06746 1/20 0.34
TRPC5 Q9UL62 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5015096 0.82 KMT2A (0.37) KMT2AMAPK8MAPK10CRHR1ALDH1A1
SCHEMBL1086866 0.76 EPHX2 (0.44) KMT2AEPHX2MAPK8MAPK10MAPT
SCHEMBL5012942 0.75 EPHX2 (0.37) KMT2AEPHX2MAPTALDH1A1MEN1
SCHEMBL5067054 0.74 KDM4E (0.36) KMT2AEPHX2KCNH2MAPTALDH1A1
SCHEMBL5011835 0.70 CYP1A2 (0.43) MAPTTHRBALDH1A1KDM4ETP53
SCHEMBL5016359 0.67 ALDH1A1 (0.38) KMT2AEPHX2ALDH1A1TSHRMEN1
SCHEMBL5011733 0.67 EPHX2 (0.39) KMT2AEPHX2ALDH1A1TSHRMEN1
SCHEMBL1086041 0.67 EPHX2 (0.44) KMT2AEPHX2MAPK8MAPK10MAPT
SCHEMBL5015097 0.66 ALDH1A1 (0.42) KMT2AKCNH2MAPTTHRBALDH1A1
SCHEMBL1085995 0.64 EPHX2 (0.47) KMT2AEPHX2MAPTALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP disclosed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO disclosed