Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 6/20 | 0.37 |
| ▸ | CNR2 | P34972 | 6/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201263 | 0.84 | SLC6A4 (0.49) | SLC6A4DRD2ALOX5CNR1CNR2 | |
| SCHEMBL5025700 | 0.72 | TLR7 (0.36) | DRD2 | |
| SCHEMBL5023889 | 0.70 | HTR2A (0.40) | — | |
| SCHEMBL5023353 | 0.70 | HTR2A (0.48) | — | |
| SCHEMBL11877556 | 0.68 | SLC6A4 (0.70) | SLC6A4DRD2ALOX5HTR1AHRH3 | |
| SCHEMBL5023775 | 0.67 | DRD2 (0.37) | DRD2HTR1ARAB9ANPC1 | |
| SCHEMBL5023822 | 0.67 | DRD2 (0.36) | DRD2HTR1ARAB9ANPC1 | |
| SCHEMBL6093432 | 0.66 | RAB9A (0.60) | DRD2HTR1ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6093435 | 0.66 | RAB9A (0.60) | DRD2HTR1ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11877235 | 0.66 | DRD2 (0.60) | SLC6A4DRD2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632483-B1 | HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMA INC (US) | 2008-10-29 | — | — | EP | claimed |