Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201266 | 0.87 | ALDH1A1 (0.35) | DRD2DRD3RAB9ANPC1MAPT | |
| SCHEMBL5023775 | 0.69 | DRD2 (0.37) | DRD2DRD3RAB9ANPC1HTR1A | |
| SCHEMBL8544362 | 0.68 | ALDH1A1 (0.47) | NPC1TSHRMAPTMEN1USP2 | |
| SCHEMBL8543289 | 0.68 | NPC1 (0.45) | RAB9ANPC1MAPT | |
| SCHEMBL8549930 | 0.67 | MCL1 (0.46) | RAB9ANPC1MCL1MAPTMEN1 | |
| SCHEMBL5016897 | 0.67 | SLC6A4 (0.47) | DRD2RAB9ANPC1HTR1A | |
| SCHEMBL8545991 | 0.66 | LMNA (0.50) | DRD2DRD3RAB9ANPC1HTR1A | |
| SCHEMBL8548519 | 0.65 | MAPT (0.47) | RAB9ANPC1TSHRMCL1MAPT | |
| SCHEMBL8543387 | 0.64 | HRH1 (0.45) | DRD2DRD3RAB9ANPC1HTR1A | |
| Hydrochloric Acid SCHEMBL8550810 | 0.64 | MAPT (0.46) | RAB9ANPC1TSHRMCL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632483-B1 | HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMA INC (US) | 2008-10-29 | — | — | EP | claimed |