SCHEMBL5019558

SCHEMBL5019558

CNN(C)c1ccc(C#N)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.47
ALDH1A1 P00352 2/20 0.46
KDM4E B2RXH2 2/20 0.46
LMNA P02545 1/20 0.46
GAA P10253 1/20 0.46
CYP2A6 P11509 2/20 0.44
CHRNB2 P17787 1/20 0.42
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
CHRNA4 P43681 1/20 0.42
HPGD P15428 1/20 0.40
HTT P42858 1/20 0.40
CA2 P00918 2/20 0.39
CA12 O43570 1/20 0.39
CA3 P07451 1/20 0.39
CA6 P23280 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
TSHR P16473 1/20 0.37
HDAC8 Q9BY41 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12440823 0.81 ALDH1A1 (0.43) LOXL2ALDH1A1KDM4ELMNAGAA
SCHEMBL3431902 0.79 KDM4E (0.45) LOXL2ALDH1A1KDM4ELMNAGAA
SCHEMBL23310396 0.78 HDAC8 (0.37) ALDH1A1CA2CA12CA9CA14
Hydrochloric Acid SCHEMBL3432097 0.78 KDM4E (0.44) LOXL2ALDH1A1KDM4ELMNAGAA
SCHEMBL60385 0.77 ALDH1A1 (0.58) LOXL2ALDH1A1KDM4ELMNAGAA
SCHEMBL8550513 0.77 CYP2A6 (0.52) LOXL2ALDH1A1KDM4ELMNAGAA
SCHEMBL28669343 0.75 CYP2A6 (0.50) LOXL2ALDH1A1KDM4ELMNAGAA
SCHEMBL3432965 0.75 CYP2A6 (0.50) LOXL2ALDH1A1KDM4ELMNAGAA
SCHEMBL6835309 0.74 ALDH1A1 (0.61) ALDH1A1KDM4EGAACYP2A6HPGD
SCHEMBL4304070 0.73 CYP2A6 (0.48) LOXL2ALDH1A1KDM4ELMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012064973-A2 HETEROCYCLIC COMPOUNDS AND USES THEREOF INFINITY PHARMACEUTICALS, INC. (US) 2012-05-18 WO disclosed
WO-2011149937-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF INTELLIKINE, INC. (US) 2011-12-01 WO disclosed
WO-2011022439-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF INTELLIKINE, INC. (US) 2011-02-24 WO disclosed
WO-2010129816-A2 HETEROCYCLIC COMPOUNDS AND USES THEREOF INTELLIKINE, INC. (US) 2010-11-11 WO disclosed