Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3432097 | 0.98 | KDM4E (0.44) | KDM4EHTTHPGDCRHBPCRHR2 | |
| SCHEMBL5019558 | 0.79 | LOXL2 (0.47) | KDM4EHTTHPGDALDH1A1CYP2A6 | |
| SCHEMBL12440823 | 0.78 | ALDH1A1 (0.43) | KDM4EHTTHPGDCRHBPCRHR2 | |
| SCHEMBL22995534 | 0.76 | KDM1A (0.53) | KDM4EHTTHPGDALDH1A1CYP2A6 | |
| SCHEMBL22299882 | 0.74 | ALDH1A1 (0.50) | HTTHPGDALDH1A1CA2CA1 | |
| SCHEMBL8550513 | 0.73 | CYP2A6 (0.52) | KDM4EALDH1A1CYP2A6CA2CA1 | |
| SCHEMBL60385 | 0.73 | ALDH1A1 (0.58) | KDM4EALDH1A1CYP2A6CA2LOXL2 | |
| SCHEMBL15718027 | 0.72 | MAPT (0.45) | KDM4EHTTHPGDCRHBPCRHR2 | |
| SCHEMBL3432965 | 0.72 | CYP2A6 (0.50) | KDM4EALDH1A1CYP2A6CA2CA1 | |
| SCHEMBL28669343 | 0.72 | CYP2A6 (0.50) | KDM4ECRHBPCRHR2ALDH1A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010146391-A1 | REGIOSELECTIVE SYNTHESIS OF LETROZOLE | GENERICS [UK] LIMITED (GB) | 2010-12-23 | — | — | WO | claimed |
| WO-2010146391-A1 | REGIOSELECTIVE SYNTHESIS OF LETROZOLE | GENERICS [UK] LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |