Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3432619 | 0.98 | CYP2A6 (0.48) | CYP2A6ALDH1A1CA2CA12CA1 | |
| SCHEMBL8550513 | 0.82 | CYP2A6 (0.52) | CYP2A6ALDH1A1CA2CA12CA1 | |
| SCHEMBL60385 | 0.82 | ALDH1A1 (0.58) | CYP2A6ALDH1A1CA2CA12LOXL2 | |
| SCHEMBL28669343 | 0.80 | CYP2A6 (0.50) | CYP2A6ALDH1A1CA2CA12LOXL2 | |
| SCHEMBL5990579 | 0.79 | LOXL2 (0.48) | CYP2A6ALDH1A1CA2CA12CA1 | |
| SCHEMBL20961863 | 0.78 | CYP2A6 (0.48) | CYP2A6ALDH1A1CA2CA12LOXL2 | |
| SCHEMBL4304070 | 0.78 | CYP2A6 (0.48) | CYP2A6ALDH1A1CA2CA12CA1 | |
| SCHEMBL7262864 | 0.76 | APP (0.53) | CYP2A6ALDH1A1CA2CA12CA1 | |
| SCHEMBL13618783 | 0.76 | CYP2A6 (0.46) | CYP2A6ALDH1A1CA2CA12LOXL2 | |
| SCHEMBL8849587 | 0.76 | ALDH1A1 (0.50) | CYP2A6ALDH1A1CA2CA12LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010146391-A1 | REGIOSELECTIVE SYNTHESIS OF LETROZOLE | GENERICS [UK] LIMITED (GB) | 2010-12-23 | — | — | WO | claimed |
| CN-119194469-B | Method for electrochemically synthesizing amine compound | 山东金科力电源科技有限公司 | 2025-02-25 | — | — | CN | disclosed |
| CN-119194469-A | Method for electrochemically synthesizing amine compound | 山东金科力电源科技有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-105164124-B | Compounds and compositions for treating parasitic diseases | 诺华股份有限公司 | 2017-03-15 | — | — | CN | disclosed |
| EP-2734520-B1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS INC (US) | 2016-09-14 | — | — | EP | disclosed |
| EP-2575462-B1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INTELLIKINE LLC (US) | 2016-06-22 | — | — | EP | disclosed |
| WO-2014151147-A1 | COMBINATION OF KINASE INHIBITORS AND USES THEREOF | INTELLIKINE, LLC (US) | 2014-09-25 | — | — | WO | disclosed |
| EP-2755953-A1 | 3 -PYRIDINE CARBOXYLIC ACID HYDRAZIDES AS HDL-CHOLESTEROL RAISING AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-23 | — | — | EP | disclosed |
| CN-103781765-A | 3-pyridine carboxylic acid hydrazides as HDL-cholesterol raising agents | HOFFMANN LA ROCHE | 2014-05-07 | — | — | CN | disclosed |
| US-8648099-B2 | 3-pyridine carboxylic acid hydrazides | HOFFMANN-LA ROCHE INC. (US) | 2014-02-11 | — | — | US | disclosed |
| WO-2013154878-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2013-10-17 | — | — | WO | disclosed |
| WO-2013078441-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INTELLIKINE, LLC (US) | 2013-05-30 | — | — | WO | disclosed |
| WO-2013037703-A1 | 3 -PYRIDINE CARBOXYLIC ACID HYDRAZIDES AS HDL-CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-21 | — | — | WO | disclosed |
| US-20130065876-A1 | 3-PYRIDINE CARBOXYLIC ACID HYDRAZIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-14 | — | — | US | disclosed |
| WO-2010146391-A1 | REGIOSELECTIVE SYNTHESIS OF LETROZOLE | GENERICS [UK] LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065876-A1 | 3-PYRIDINE CARBOXYLIC ACID HYDRAZIDES | HMGCR, HCAR3, HCAR1 | CYP2A6 269/4885ALDH1A1 172/4885CA2 688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.