Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825366 | 0.87 | IL2 (0.44) | KDM4EMAP3K5IL2 | |
| SCHEMBL3827961 | 0.86 | HTR1F (0.42) | CSNK1DCSNK1EDYRK1AGSK3BMAP3K5 | |
| SCHEMBL4999489 | 0.85 | HDAC4 (0.35) | KDM4EDYRK1AGSK3BWNT1 | |
| SCHEMBL5019718 | 0.85 | THRB (0.36) | KDM4EDYRK1AMAP3K5WNT1IL2 | |
| SCHEMBL10819910 | 0.85 | MAP3K5 (0.39) | KDM4EDYRK1AGSK3BMAP3K5WNT1 | |
| SCHEMBL3826508 | 0.84 | KMT2A (0.47) | KDM4ECSNK1DCSNK1EDYRK1AGSK3B | |
| SCHEMBL8186422 | 0.84 | IL2 (0.40) | KDM4EDYRK1AGSK3BMAP3K5WNT1 | |
| SCHEMBL5019746 | 0.84 | MAP3K5 (0.33) | DYRK1AGSK3BMAP3K5WNT1IL2 | |
| SCHEMBL12650398 | 0.83 | IL2 (0.40) | KDM4EDYRK1AGSK3BMAP3K5WNT1 | |
| SCHEMBL3824488 | 0.83 | IL2 (0.42) | IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |