Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780512 | 0.93 | THRB (0.35) | THRBABL1NPC1RAB9AMAP3K5 | |
| SCHEMBL3827961 | 0.90 | HTR1F (0.42) | NPC1RAB9AMAP3K5IL2TP53 | |
| SCHEMBL10819910 | 0.85 | MAP3K5 (0.39) | NPC1RAB9AMAP3K5IL2TP53 | |
| SCHEMBL5019623 | 0.85 | PTPN11 (0.34) | NPC1RAB9AMAP3K5IL2WNT1 | |
| SCHEMBL3826508 | 0.85 | KMT2A (0.47) | ABL1NPC1RAB9AMAP3K5TP53 | |
| SCHEMBL5019588 | 0.85 | GRM5 (0.36) | MAP3K5IL2KDM4EWNT1DYRK1A | |
| SCHEMBL3824488 | 0.84 | IL2 (0.42) | IL2P2RX7STIM1ORAI1ORAI2 | |
| SCHEMBL5019579 | 0.84 | KMT2A (0.39) | NPC1RAB9AMAP3K5IL2TP53 | |
| SCHEMBL5019603 | 0.84 | KMT2A (0.39) | NPC1RAB9AMAP3K5IL2TP53 | |
| SCHEMBL5019754 | 0.84 | GRM5 (0.40) | THRBTP53LMNAIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |