Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.38 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.38 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.38 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 6/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019572 | 0.95 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL18791615 | 0.82 | ADORA2A (0.38) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL5019581 | 0.81 | NPC1 (0.50) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL15627123 | 0.80 | NPC1 (0.49) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL5019574 | 0.80 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL4562161 | 0.80 | NPC1 (0.49) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL5019571 | 0.78 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL4561661 | 0.78 | RAB9A (0.44) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL5019596 | 0.78 | ADORA2A (0.48) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL4561922 | 0.77 | NPC1 (0.46) | NPC1RAB9AALDH1A1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170112845-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | US | disclosed |
| US-20170112845-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | US | disclosed |
| EP-2637659-B1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS INC (US) | 2016-05-18 | — | — | EP | disclosed |
| US-20150250795-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-09-10 | — | — | US | disclosed |
| US-20150250795-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-09-10 | — | — | US | disclosed |
| US-9061030-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9061030-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140088071-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20140088071-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2012064559-A1 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250795-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | NPC1 2967/4885RAB9A 2039/4885ALDH1A1 1239/4885 |
| US-20140088071-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | NPC1 3154/4885RAB9A 2122/4885ALDH1A1 1223/4885 |
| US-20170112845-A1 | sGC STIMULATORS | PTGIS, GUCY1B1, GUCY1A1 | NPC1 2967/4885RAB9A 2039/4885ALDH1A1 1239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.