Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019706 | 0.92 | MAPT (0.33) | MAPTPOLBPTPN11KMT2AKCNH2 | |
| SCHEMBL5019710 | 0.92 | MAPT (0.34) | MAPTPOLBPTPN11KDM4EALDH1A1 | |
| SCHEMBL5019713 | 0.85 | SMYD3 (0.37) | MAPTPOLBPTPN11ALDH1A1HPGD | |
| SCHEMBL5019621 | 0.84 | KDM4E (0.38) | MAPTPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL5019624 | 0.84 | MAPT (0.40) | MAPTPOLBPTPN11ALDH1A1SMN1; SMN2 | |
| SCHEMBL4561040 | 0.82 | KMT2A (0.35) | MAPTPTPN11TSHRRAB9AKMT2A | |
| SCHEMBL5019578 | 0.81 | MAPT (0.36) | MAPTPOLBPTPN11ALDH1A1SMN1; SMN2 | |
| SCHEMBL986998 | 0.78 | STIM1 (0.42) | PTPN11KMT2A | |
| SCHEMBL15356925 | 0.78 | CYP11B2 (0.31) | CYP11B2 | |
| SCHEMBL5019751 | 0.78 | RAB9A (0.38) | MAPTPOLBPTPN11KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |