Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823860 | 0.90 | NPC1 (0.48) | SMN1; SMN2TP53GAADYRK1AGSK3B | |
| SCHEMBL1781784 | 0.88 | SMO (0.44) | SMN1; SMN2LMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL3823063 | 0.87 | L3MBTL1 (0.40) | ALDH1A1HTTKMT2AMEN1 | |
| SCHEMBL5019599 | 0.87 | SMN1; SMN2 (0.40) | SMN1; SMN2TP53GAADYRK1AGSK3B | |
| SCHEMBL5019711 | 0.84 | GRM5 (0.40) | DYRK1AGSK3BF10 | |
| SCHEMBL3823169 | 0.84 | HTR1F (0.44) | SMN1; SMN2TP53LMNAGAADYRK1A | |
| SCHEMBL5005018 | 0.84 | IL2 (0.41) | SMN1; SMN2TP53GAADYRK1AGSK3B | |
| SCHEMBL10819914 | 0.83 | NPC1 (0.40) | SMN1; SMN2TP53GAADYRK1AGSK3B | |
| SCHEMBL5019716 | 0.81 | RAB9A (0.47) | SMN1; SMN2TP53LMNARAB9ANPC1 | |
| SCHEMBL16472095 | 0.81 | IL2 (0.37) | SMN1; SMN2TP53GAADYRK1AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |