Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3827961 | 0.90 | HTR1F (0.42) | HTR1FMAP3K5TP53ALDH1A1LMNA | |
| SCHEMBL10819910 | 0.83 | MAP3K5 (0.39) | HTR1FMAP3K5TP53ALDH1A1NPC1 | |
| SCHEMBL1780512 | 0.81 | THRB (0.35) | MAP3K5TP53ALDH1A1NPC1RAB9A | |
| SCHEMBL3823169 | 0.81 | HTR1F (0.44) | HTR1FMAP3K5TP53ALDH1A1LMNA | |
| SCHEMBL5019718 | 0.80 | THRB (0.36) | MAP3K5TP53ALDH1A1LMNANPC1 | |
| SCHEMBL3826508 | 0.80 | KMT2A (0.47) | HTR1FMAP3K5TP53ALDH1A1NPC1 | |
| SCHEMBL5019762 | 0.79 | HTR1F (0.42) | HTR1FMAP3K5TP53ALDH1A1LMNA | |
| SCHEMBL15386459 | 0.78 | IL2 (0.39) | HTR1FMAP3K5ALDH1A1NPC1RAB9A | |
| SCHEMBL12848849 | 0.78 | HTR1F (0.40) | HTR1FMAP3K5TP53ALDH1A1LMNA | |
| SCHEMBL5019746 | 0.78 | MAP3K5 (0.33) | MAP3K5WNT1GSK3BDYRK1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |