Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1690457 | 0.85 | CYP2A6 (0.68) | CYP11B1CYP11B2CYP2A6MKNK1MKNK2 | |
| SCHEMBL9413197 | 0.81 | MAP4K4 (0.51) | FDPSTAAR1CYP2A6MKNK1MKNK2 | |
| SCHEMBL9413172 | 0.81 | CYP2A6 (0.44) | FDPSCYP11B1CYP11B2CYP2A6PRMT5 | |
| SCHEMBL9413189 | 0.81 | CYP2A6 (0.44) | FDPSCYP11B1CYP11B2TAAR1CYP2A6 | |
| SCHEMBL7393289 | 0.81 | DRD2 (0.52) | FDPSCYP11B1CYP11B2TAAR1CYP2A6 | |
| SCHEMBL9413179 | 0.80 | CYP2A6 (0.45) | FDPSTAAR1CYP2A6PRMT5WDR77 | |
| SCHEMBL2646363 | 0.80 | CYP11B1 (0.54) | FDPSCYP11B1CYP11B2MKNK1MKNK2 | |
| SCHEMBL10271979 | 0.80 | CYP11B1 (0.54) | FDPSCYP11B1CYP11B2MKNK1MKNK2 | |
| SCHEMBL5456894 | 0.80 | CYP11B1 (0.54) | FDPSCYP11B1CYP11B2MKNK1MKNK2 | |
| SCHEMBL5021553 | 0.80 | FDPS (0.57) | FDPSCYP11B1CYP11B2CYP2A6MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410155-B2 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-02 | — | — | US | disclosed |
| US-20120283264-A1 | Oxazolidinones as Modulators of MGLUR5 | BRISTOL-MYERS SQUIBB COMPANY | 2012-11-08 | — | — | US | disclosed |
| WO-2012064603-A1 | OXAZOLIDINONES AS MODULATORS OF MGLUR5 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-05-18 | — | — | WO | disclosed |
| US-7618988-B2 | (2R,4R)-2-({[5-(4-fluorophenyl)-pyridin 3ylmethyl]-amino}-methyl)-chroman-4-ol; extrapyramidal symptoms (EPS) induced by neuroleptics; Parkinson's disease | MERCK PATENTGESELLSCHAFT (DE) | 2009-11-17 | — | — | US | disclosed |
| US-7618988-B2 | (2R,4R)-2-({[5-(4-fluorophenyl)-pyridin 3ylmethyl]-amino}-methyl)-chroman-4-ol; extrapyramidal symptoms (EPS) induced by neuroleptics; Parkinson's disease | MERCK PATENTGESELLSCHAFT (DE) | 2009-11-17 | — | — | US | disclosed |
| EP-1587473-A4 | THIOSEMICARBAZONES AS ANTI-VIRALS AND IMMUNOPOTENTIATORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-08-13 | — | — | EP | disclosed |
| CN-1246319-C | Amino (thio) ether derivative | MERCK PATENT AG (DE) | 2006-03-22 | — | — | CN | disclosed |
| EP-1587473-A2 | THIOSEMICARBAZONES AS ANTI-VIRALS AND IMMUNOPOTENTIATORS | CHIRON CORPORATION (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004060308-A2 | THIOSEMICARBAZONES AS ANTI-VIRALS AND IMMUNOPOTENTIATORS | CHIRON CORPORATION (US) | 2004-07-22 | — | — | WO | disclosed |
| EP-1123933-A1 | 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane as CNS active agent | MERCK PATENT GmbH (DE) | 2001-08-16 | — | — | EP | disclosed |
| US-5767132-A | CENTRAL NERVOUS SYSTEM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-06-16 | — | — | US | disclosed |
| CN-1130180-A | Amino (thio) ether derivative | MERCK PATENT AG (DE) | 1996-09-04 | — | — | CN | disclosed |
| EP-0707007-A1 | Amino(thio)ether derivatives as CNS active agents | MERCK PATENT GmbH (DE) | 1996-04-17 | — | — | EP | disclosed |
| EP-0586866-A2 | 1,4,-Benzodioxane derivatives with pharmacologic properties | MERCK PATENT GmbH (DE) | 1994-03-16 | — | — | EP | disclosed |
| EP-0180794-B1 | PYRIDINE DERIVATIVES | MERCK PATENT GmbH (DE) | 1989-05-31 | — | — | EP | disclosed |
| US-4760082-A | Certain di-aryl-1,2,3,6-tetrahydro-pyridyl-n-lower-alkylene-pyridines having neuroleptic properties | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-07-26 | — | — | US | disclosed |
| US-4665187-A | Certain 1,2,3,6-tetrahydro-pyridyl-N-lower-alkanoyl-pyridines as intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-05-12 | — | — | US | disclosed |
| EP-0180794-A1 | Pyridine derivatives | MERCK PATENT GmbH (DE) | 1986-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283264-A1 | Oxazolidinones as Modulators of MGLUR5 | GRM5, GRIK5, GRM1 | FDPS 3269/4885CYP11B1 1852/4885CYP11B2 1547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.