Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.51 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 4/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL475933 | 0.94 | ZDHHC20 (0.58) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| SCHEMBL2803754 | 0.92 | ZDHHC20 (0.59) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| Bromide SCHEMBL1667281 | 0.90 | ZDHHC20 (0.58) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| Hydrochloric Acid SCHEMBL30033466 | 0.89 | ZDHHC20 (0.61) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| Bromide SCHEMBL30032600 | 0.85 | ZDHHC20 (0.61) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| Acrylic Acid SCHEMBL360506 | 0.84 | ZDHHC20 (0.50) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| Acrylic Acid SCHEMBL19207252 | 0.84 | ZDHHC20 (0.50) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| Hydrochloric Acid SCHEMBL475906 | 0.83 | ZDHHC20 (0.52) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| SCHEMBL1200572 | 0.81 | ZDHHC20 (0.53) | ZDHHC20ZDHHC2GAAKMT2AATM | |
| SCHEMBL28417958 | 0.80 | ZDHHC20 (0.68) | ZDHHC20ZDHHC2GAAKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080102143-A1 | Uses for the Extract of a Plant of the Family Asclepiadaceae | COGNIS FRANCE S.A.S. (FR) | 2008-05-01 | — | — | US | disclosed |