Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 6/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026568 | 0.88 | XDH (0.71) | XDHMAOBALDH1A1 | |
| SCHEMBL30141105 | 0.83 | KMT2A (0.62) | SLC6A2SLC6A3KMT2ATDP1LMNA | |
| SCHEMBL3960907 | 0.83 | KMT2A (0.62) | SLC6A2SLC6A3KMT2ATDP1LMNA | |
| SCHEMBL2428492 | 0.83 | TDP1 (0.54) | XDHSLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL3960881 | 0.81 | LMNA (0.62) | SLC6A2SLC6A3KMT2ATDP1LMNA | |
| SCHEMBL1647432 | 0.81 | TDP1 (0.58) | SLC6A2SLC6A3KMT2ATDP1LMNA | |
| SCHEMBL8143434 | 0.81 | HPGD (0.54) | XDHLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28587139 | 0.80 | XDH (0.55) | XDHMAOB | |
| SCHEMBL1329717 | 0.80 | XDH (0.55) | XDHMAOB | |
| SCHEMBL23226754 | 0.80 | FFAR4 (0.59) | SLC6A2SLC6A3KMT2ATDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092072-A2 | MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 AND USES THEREOF | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-07-31 | — | — | WO | disclosed |