Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4170972 | 0.83 | MAPT (0.48) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL20565594 | 0.82 | ALDH1A1 (0.56) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL31297178 | 0.79 | SHMT2 (0.59) | MAPTSHMT2ALDH1A1KDM4EKMT2A | |
| SCHEMBL5025161 | 0.78 | MAPT (0.51) | MAPTSHMT2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6800240 | 0.77 | L3MBTL1 (0.52) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL5022271 | 0.77 | ALDH1A1 (0.56) | MAPTSHMT2ALDH1A1KDM4EKMT2A | |
| SCHEMBL13125313 | 0.76 | TSHR (0.53) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL4994166 | 0.75 | MAPT (0.43) | MAPTSHMT2ALDH1A1KDM4EKMT2A | |
| SCHEMBL873632 | 0.75 | MAPT (0.58) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL6795770 | 0.75 | MEN1 (0.53) | MAPTALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361658-B2 | 1-{3-chloro-5-[(4-(4-chlorothiophen-2-yl)-5-{[cyclobutyl(methyl)amino]methyl}thiazol-2-yl)carbamoyl]-2-pyridyl)piperidine-4-carboxylic acid; non-peptide thrombopoietin receptor (c-mpl-Ba/F3) ligand; less immunogenicity; platelet activator based on megakaryocyte colony; thrombocytopenia; orally | ASTELLAS PHARMA INC. (JP) | 2008-04-22 | — | — | US | disclosed |
| US-20060194844-A1 | 2-Acylaminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2006-08-31 | — | — | US | disclosed |
| EP-1647553-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2006-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194844-A1 | 2-Acylaminothiazole derivative or salt thereof | MPL, JAK2, MATK | MAPT 4790/4885SHMT2 2746/4885ALDH1A1 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.