Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26035520 | 0.87 | MAPT (0.48) | MAPTSMN1; SMN2POLBTP53HTT | |
| SCHEMBL3050870 | 0.81 | SMN1; SMN2 (0.65) | MAPTSMN1; SMN2POLBTP53HTT | |
| SCHEMBL21500013 | 0.76 | POLB (0.46) | MAPTSMN1; SMN2POLBHTTAPP | |
| SCHEMBL3060967 | 0.75 | MAPT (0.56) | MAPTSMN1; SMN2POLBTP53HTT | |
| SCHEMBL3051333 | 0.74 | MAPT (0.54) | MAPTSMN1; SMN2POLBTP53HTT | |
| SCHEMBL17249531 | 0.74 | GAA (0.66) | MAPTSMN1; SMN2POLBTP53HTT | |
| SCHEMBL3907319 | 0.73 | L3MBTL1 (0.70) | MAPTSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL26035496 | 0.72 | MAPT (0.57) | MAPTSMN1; SMN2POLBTP53HTT | |
| SCHEMBL22542703 | 0.72 | GAA (0.48) | MAPTSMN1; SMN2POLBTP53HTT | |
| SCHEMBL21499795 | 0.71 | MAPT (0.54) | MAPTSMN1; SMN2POLBTP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450333-B2 | Molecules for regulating cell death | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450333-B2 | Molecules for regulating cell death | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450333-B2 | Molecules for regulating cell death | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-28 | — | — | US | disclosed |
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-20 | — | — | US | disclosed |
| US-20050038051-A1 | Novel molecules for regulating cell death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | AIFM1, BAX, HSPE1 | MAPT 3063/4885SMN1; SMN2 2685/4885POLB 3457/4885 |
| US-20050038051-A1 | Novel molecules for regulating cell death | AIFM1, BAX, HSPE1 | MAPT 3063/4885SMN1; SMN2 2685/4885POLB 3457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.