Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057541 | 0.83 | MAOB (0.44) | ALDH1A1L3MBTL1MAOBDAO | |
| SCHEMBL7819517 | 0.82 | DAO (0.50) | MAOBDAO | |
| SCHEMBL11293978 | 0.82 | CHRM2 (0.53) | — | |
| Hydrochloric Acid SCHEMBL5039722 | 0.81 | IGF1R (0.38) | IGF1RALOX15TAAR1ALDH1A1L3MBTL1 | |
| SCHEMBL6505678 | 0.80 | NR1H2 (0.41) | ALDH1A1L3MBTL1DAO | |
| SCHEMBL5176963 | 0.79 | ESR1 (0.46) | IGF1RALOX15TAAR1ALDH1A1HTR3A | |
| SCHEMBL3872946 | 0.79 | ALDH1A1 (0.33) | ALDH1A1L3MBTL1 | |
| SCHEMBL11299345 | 0.78 | CHRM2 (0.47) | ALDH1A1 | |
| SCHEMBL15599121 | 0.76 | SIGMAR1 (0.47) | TAAR1HDAC1HDAC8 | |
| SCHEMBL11327663 | 0.75 | ALDH1A1 (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153870-A1 | COCAINE RECEPTOR BINDING LIGANDS | RESEARCH TRIANGLE INSTITUTE (US) | 2008-06-26 | — | — | US | disclosed |
| US-7291737-B2 | Cocaine receptor binding ligands | RESEARCH TRIANGLE INSTITUTE (US) | 2007-11-06 | — | — | US | disclosed |
| US-7189737-B2 | Cocaine receptor binding ligands | RESEARCH TRIANGLE INSTITUTE (US) | 2007-03-13 | — | — | US | disclosed |
| US-20050197360-A1 | Cocaine receptor binding ligands | RESEARCH TRIANGLE INSTITUTE (US) | 2005-09-08 | — | — | US | disclosed |
| US-6706880-B2 | USED AS IMAGING OR PHARMACEUTICAL AGENTS, IN THE DIAGNOSIS AND THERAPY OF DRUG ADDICTION, DEPRESSION, ANOREXIA AND NEURODEGENERATIVE DISEASES | RESEARCH TRIANGLE INSTITUTE | 2004-03-16 | — | — | US | disclosed |
| US-20030203934-A1 | Cocaine receptor binding ligands | RESEARCH TRIANGLE INSTITUTE (US) | 2003-10-30 | — | — | US | disclosed |
| US-6531483-B1 | Treating psychostimulant abuse, inhibiting action of psychostimulant, inhibiting neurotransmitter re-uptake, treating Parkinson's Disease, treating depression | RESEARCH TRIANGLE INSTITUTE | 2003-03-11 | — | — | US | disclosed |
| US-20030023090-A1 | Cocaine receptor binding ligands | RESEARCH TRIANGLE INSTITUTE | 2003-01-30 | — | — | US | disclosed |
| EP-1079833-A4 | COCAINE RECEPTOR BINDING LIGANDS | RES TRIANGLE INST (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6329520-B1 | USED AS IMAGING OR PHARMACEUTICAL AGENTS, IN THE DIAGNOSIS AND TREATMENT OF DRUG ADDICTION, DEPRESSION, ANOREXIA AND NEURODEGENERATIVE DISEASES OR IN DETERMINING DOSES OF THERAPEUTIC AGENTS THAT OCCUPY MANY RECEPTORS | RESEARCH TRIANGLE INSTITUTE | 2001-12-11 | — | — | US | disclosed |
| EP-1079833-A1 | COCAINE RECEPTOR BINDING LIGANDS | RESEARCH TRIANGLE INSTITUTE (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061023-A1 | COCAINE RECEPTOR BINDING LIGANDS | RESEARCH TRIANGLE INSTITUTE (US) | 1999-12-02 | — | — | WO | disclosed |
| US-5935953-A | TROPANE DERIVATIVES AS INHIBITORS TO REDUCE THE FEEDING OF AND DELAYING THE MATURATION OF THE INSECTS AND PESTS; INHIBITORS OF A PHENYLETHANOLAMINE, E.G.OCTOPAMINE, REUPTAKE TRANSPORTER; PESTICIDES; PESTISTATS; INSECTICIDES | RESEARCH TRIANGLE INSTITUTE (US) | 1999-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153870-A1 | COCAINE RECEPTOR BINDING LIGANDS | SLC18A2, SLC6A3, SLC18A3 | IGF1R 725/4885ALOX15 4235/4885TAAR1 8/4885 |
| US-20030023090-A1 | Cocaine receptor binding ligands | OPRL1, SLC18A2, SLC6A3 | IGF1R 316/4885ALOX15 3995/4885TAAR1 4/4885 |
| US-20050197360-A1 | Cocaine receptor binding ligands | SLC18A2, SLC6A3, SLC18A3 | IGF1R 725/4885ALOX15 4235/4885TAAR1 8/4885 |
| US-20030203934-A1 | Cocaine receptor binding ligands | SLC18A2, SLC6A3, SLC18A3 | IGF1R 725/4885ALOX15 4235/4885TAAR1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.