Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.39 |
| ▸ | VPS4B | O75351 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 5/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 3/20 | 0.32 |
| ▸ | HTR1B | P28222 | 2/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902826 | 0.88 | AR (0.39) | ARVPS4BVCPHTR1ANR2E1 | |
| SCHEMBL4909034 | 0.79 | SIRT1 (0.55) | ARSLC6A4HTR1ASIRT1HTR1B | |
| SCHEMBL4902847 | 0.76 | SIRT1 (0.52) | VPS4BVCPHTR1ANR2E1SIRT1 | |
| SCHEMBL4895997 | 0.76 | SIRT1 (0.44) | ARSLC6A4HTR1ACDK2FLT3 | |
| SCHEMBL14040261 | 0.75 | AR (0.42) | ARVPS4BVCPNR2E1SIRT1 | |
| SCHEMBL4904688 | 0.74 | VPS4B (0.39) | ARVPS4BVCPSLC6A4HTR1A | |
| SCHEMBL4900711 | 0.74 | VPS4B (0.58) | VPS4BVCPSLC6A4HTR1ADRD2 | |
| SCHEMBL4900652 | 0.74 | VPS4B (0.58) | VPS4BVCPSLC6A4HTR1ADRD2 | |
| SCHEMBL5026464 | 0.73 | AR (0.52) | ARHTR2AHTR2BHTR2C | |
| SCHEMBL14040246 | 0.72 | AR (0.35) | ARVPS4BVCPHTR1ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | claimed |
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | claimed |
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | WYETH (US) | 2006-09-14 | — | — | US | claimed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | claimed |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2008-04-03 | — | — | US | disclosed |
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | disclosed |
| US-7297704-B2 | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | WYETH (US) | 2006-09-14 | — | — | US | disclosed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205759-A1 | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives | TPH1, TPH2, HTR2C | AR 933/4885VPS4B 4111/4885VCP 4032/4885 |
| US-20080081910-A1 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | TPH1, TPH2, HTR2C | AR 933/4885VPS4B 4111/4885VCP 4032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.