Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | EDNRB | P24530 | 3/20 | 0.36 |
| ▸ | EDNRA | P25101 | 3/20 | 0.36 |
| ▸ | IL2 | P60568 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5030761 | 0.76 | IL2 (0.49) | NFE2L2EDNRBEDNRAIL2KCNH2 | |
| SCHEMBL5030758 | 0.76 | IL2 (0.49) | NFE2L2EDNRBEDNRAIL2KCNH2 | |
| SCHEMBL8628488 | 0.69 | HPGDS (0.51) | EDNRBEDNRAIL2HPGDSIMPDH2 | |
| SCHEMBL27448711 | 0.69 | HPGDS (0.47) | EDNRBEDNRAHPGDSIMPDH2LTA4H | |
| SCHEMBL5027336 | 0.68 | IL2 (0.48) | EDNRBEDNRAIL2HCRTR1HCRTR2 | |
| SCHEMBL5027329 | 0.68 | IL2 (0.48) | EDNRBEDNRAIL2HCRTR1HCRTR2 | |
| SCHEMBL30632951 | 0.68 | NFE2L2 (0.44) | NFE2L2KDM4EKCNH2HPGD | |
| SCHEMBL5028468 | 0.68 | IL2 (0.54) | IL2HPGD | |
| SCHEMBL5028469 | 0.68 | IL2 (0.54) | IL2HPGD | |
| SCHEMBL5029757 | 0.66 | IL2 (0.48) | EDNRBEDNRAIL2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983971-A2 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087441-A2 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | disclosed |