Sugi Predict

Sugi Predict / Compounds / SCHEMBL502852

SCHEMBL502852

SCHEMBL502852

C#Cc1cnc2[nH]ncc2c1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PARP1 P09874 1/20 0.37
▸ BRAF P15056 6/20 0.36
▸ PIK3C3 Q8NEB9 3/20 0.35
▸ RET P07949 1/20 0.34
▸ PI4KA P42356 1/20 0.34
▸ XDH P47989 1/20 0.34
▸ LRRK2 Q5S007 1/20 0.34
▸ PI4K2B Q8TCG2 1/20 0.34
▸ PI4K2A Q9BTU6 1/20 0.34
▸ PI4KB Q9UBF8 1/20 0.34
▸ MAP3K20 Q9NYL2 1/20 0.34
▸ EGLN1 Q9GZT9 1/20 0.33
▸ IDO1 P14902 1/20 0.33
▸ AKT1 P31749 1/20 0.33
▸ PIK3CA P42336 1/20 0.33
▸ EGFR P00533 1/20 0.32
▸ PRKDC P78527 1/20 0.32
▸ PDPK1 O15530 1/20 0.32
▸ ABL1 P00519 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30726289 0.80 KDM4E (0.41) BRAFPIK3C3RETPI4KAXDH
SCHEMBL293195 0.73 RIPK1 (0.51) RETLRRK2MAP3K20PIK3CAEGFR
SCHEMBL1586122 0.73 CYP2C19 (0.42) BRAFPIK3C3RETPI4KAXDH
SCHEMBL1519704 0.71 ROCK2 (0.53) IDO1
SCHEMBL12344590 0.70 PIK3C3 (0.37) BRAFPIK3C3RETPI4KAXDH
SCHEMBL17316253 0.69 PARP1 (0.39) PARP1EGLN1
SCHEMBL11982852 0.68 PIK3C3 (0.36) BRAFPIK3C3RETPI4KAXDH
SCHEMBL20674185 0.68 FGFR1 (0.40) BRAFPIK3C3RETPI4KAXDH
SCHEMBL3429629 0.68 PIK3C3 (0.36) BRAFPIK3C3RETPI4KAXDH
SCHEMBL10329 0.68 DYRK1A (0.50) PIK3C3RETLRRK2MAP3K20ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250129068-A1 4-(2-PYRAZOLO[3,4-B]PYRIDINE-5-YL)ETHYNYL-2-PYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS IP2IPO INNOVATIONS LIMITED (GB) 2025-04-24 — — US disclosed
CN-119661503-A 4-Ethynyl pyridine derivatives as GCN2 inhibitors IP2IPO创新有限公司 2025-03-21 — — CN disclosed
CN-116113629-B 4-Ethynyl pyridine derivatives as GCN2 inhibitors IP2IPO创新有限公司 2024-12-31 — — CN disclosed
EP-4448520-A1 4-(2-PYRAZOLO[3,4-B]PYRIDINE-5-YL)ETHYNYL-2-PYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS IP2IPO Innovations Limited (GB) 2024-10-23 — — EP disclosed
US-20240150345-A1 GCN2 MODULATING COMPOUNDS AND USES THEREOF PHARMARON UK LTD. (GB) 2024-05-09 — — US disclosed
US-11945799-B2 4-ethynylpyridine derivatives useful as GCN2 inhibitors IP2IPO INNOVATIONS LIMITED (GB) 2024-04-02 — — US disclosed
US-20230390416-A1 COMPOSITIONS FOR INDUCING TUMOR IMMUNITY AND REDUCING DRUG TOLERANCE THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2023-12-07 — — US disclosed
US-20230271939-A1 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS IP2IPO INNOVATIONS LIMITED (GB) 2023-08-31 — — US disclosed
US-20230271939-A1 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS IP2IPO INNOVATIONS LIMITED (GB) 2023-08-31 — — US disclosed
US-20230271939-A1 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS IP2IPO INNOVATIONS LIMITED (GB) 2023-08-31 — — US disclosed
US-20110281838-A1 5-ALKYNYL-PYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-11-17 — — US disclosed
US-20110281838-A1 5-ALKYNYL-PYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-11-17 — — US disclosed
US-20110281838-A1 5-ALKYNYL-PYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-11-17 — — US disclosed
WO-2011092197-A1 5-ALKYNYL PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-08-04 — — WO disclosed
WO-2011092198-A1 5-ALKYNYL-PYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-08-04 — — WO disclosed
US-20110098275-A1 5-ALKYNYL-PYRIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-04-28 — — US disclosed
US-20110098275-A1 5-ALKYNYL-PYRIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-04-28 — — US disclosed
US-20110098275-A1 5-ALKYNYL-PYRIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-04-28 — — US disclosed
WO-2010122069-A1 5-ALKYNYL-PYRIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-10-28 — — WO disclosed
WO-2010012740-A1 5-ALKYNYL-PYRIMIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-02-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230271939-A1 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS EIF2AK4, GCN1, EIF5B PARP1 1671/4885BRAF 2826/4885PIK3C3 2472/4885
US-20110281838-A1 5-ALKYNYL-PYRIMIDINES MKI67, CCNA1, CCNT1 PARP1 86/4885BRAF 677/4885PIK3C3 3615/4885
US-20250129068-A1 4-(2-PYRAZOLO[3,4-B]PYRIDINE-5-YL)ETHYNYL-2-PYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS EIF2AK4, GCN1, GCGR PARP1 1831/4885BRAF 1152/4885PIK3C3 2872/4885
US-20240150345-A1 GCN2 MODULATING COMPOUNDS AND USES THEREOF EIF2AK4, GCN1, CLN6 PARP1 3410/4885BRAF 2092/4885PIK3C3 4585/4885
US-20230390416-A1 COMPOSITIONS FOR INDUCING TUMOR IMMUNITY AND REDUCING DRUG TOLERANCE HSP90AB1, HSP90AA1, HSP90AB2P PARP1 4100/4885BRAF 1469/4885PIK3C3 3952/4885
US-20110098275-A1 5-ALKYNYL-PYRIDINES MKI67, KIT, CCNA1 PARP1 447/4885BRAF 357/4885PIK3C3 4308/4885
US-11945799-B2 4-ethynylpyridine derivatives useful as GCN2 inhibitors EIF2AK4, GCN1, EIF5B PARP1 1671/4885BRAF 2826/4885PIK3C3 2472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.