Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | PHGDH | O43175 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444671 | 0.92 | CNR2 (0.44) | ALDH1A1MGLLPHGDHHPGDTSHR | |
| SCHEMBL5028952 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HPGDPDE2APOLB | |
| SCHEMBL5029162 | 0.81 | AKR1C3 (0.41) | — | |
| SCHEMBL3375071 | 0.81 | USP30 (0.44) | PHGDHPDE10APDE2A | |
| SCHEMBL3374491 | 0.81 | USP30 (0.44) | PHGDHPDE10APDE2A | |
| SCHEMBL23222307 | 0.81 | PHGDH (0.43) | PHGDHHSD17B10PDE10ADRD3PDE2A | |
| SCHEMBL19049367 | 0.79 | PHGDH (0.42) | PHGDHPDE10APDE2A | |
| SCHEMBL2295521 | 0.79 | PDE10A (0.43) | PDE10APDE2A | |
| SCHEMBL20665200 | 0.79 | RIPK1 (0.44) | PHGDHPDE10ADRD3PDE2A | |
| SCHEMBL19002796 | 0.79 | EPHX2 (0.43) | DRD3PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007393-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118149-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL LOLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |