Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862508 | 0.83 | PTGER1 (0.45) | KMT2APTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL5272384 | 0.81 | KMT2A (0.61) | KMT2APTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4375768 | 0.79 | KMT2A (0.53) | KMT2APTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL5912626 | 0.78 | PDCD1 (0.50) | KMT2APTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL2870992 | 0.73 | KMT2A (0.47) | KMT2AKCNA5MMEACECPA1 | |
| SCHEMBL1338716 | 0.73 | KMT2A (0.47) | KMT2APTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9890646 | 0.73 | PTGER1 (0.57) | KMT2APTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL29398181 | 0.73 | RAB9A (0.50) | KMT2AMAOBMEN1NPC1SMN1; SMN2 | |
| SCHEMBL5805651 | 0.73 | RAB9A (0.50) | KMT2AMAOBMEN1NPC1SMN1; SMN2 | |
| SCHEMBL1337563 | 0.72 | CD274 (0.47) | KMT2APTGER1PTGER4PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101360714-A | Novel 2-amino-heterocycles useful in the treatment of abeta-related pathologies | ASTRAZENECA AB (SE) | 2009-02-04 | — | — | CN | disclosed |
| EP-1957462-A2 | NOVEL 2-AMINO-HETEROCYCLES UDEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | Astra Zeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007058583-A2 | NOVEL 2-AMINO-HETEROCYCLES USEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |