Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2529641 | 0.78 | — | — | |
| SCHEMBL9543621 | 0.72 | MEN1 (0.36) | MEN1THRBRECQLKMT2AALDH1A1 | |
| SCHEMBL1302787 | 0.61 | — | — | |
| Dienochlor SCHEMBL117767 | 0.58 | MEN1 (1.00) | MEN1THRBRECQLKMT2AALDH1A1 | |
| SCHEMBL7625810 | 0.58 | MEN1 (0.57) | MEN1THRBRECQLKMT2AALDH1A1 | |
| SCHEMBL165983 | 0.58 | ALDH1A1 (1.00) | MEN1THRBRECQLKMT2AALDH1A1 | |
| Cyclooctane SCHEMBL3271413 | 0.58 | ALDH1A1 (0.79) | MEN1THRBRECQLKMT2AALDH1A1 | |
| SCHEMBL28514625 | 0.56 | — | — | |
| Dienochlor SCHEMBL7050079 | 0.56 | MEN1 (0.92) | MEN1THRBRECQLKMT2AALDH1A1 | |
| SCHEMBL9720387 | 0.56 | ALDH1A1 (0.92) | MEN1THRBRECQLKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335659-B2 | Substituted 10-aryl-11H-benzo[b]fluorenes and 7-aryl-5, 6-dihydro-benzo[a]anthracenes for selective effects on estrogen receptors | N.V. ORGANON (NL) | 2008-02-26 | — | — | US | disclosed |
| EP-1478613-B1 | SUBSTITUTED 10-ARYL-11H-BENZO¬B|FLUORENES FOR SELECTIVE EFFECTS ON ESTROGEN RECEPTORS | AKZO NOBEL NV (NL) | 2006-05-24 | — | — | EP | disclosed |
| EP-1313700-B1 | 10-ARYL-11H-BENZO[B]FLUORENE DERIVATIVES AND ANALOGS AS ESTROGENIC COMPOUNDS | AKZO NOBEL NV (NL) | 2005-11-09 | — | — | EP | disclosed |
| US-20050159405-A1 | Substituted 10-aryl-11h-benzo[b]fluourenes and 7-aryl-5, 6-dihydro-benzo[a]anthracenes for selective effects on estrogen receptors | AKZO NOBEL, N.V. PATENT DEPARTMENT (NL) | 2005-07-21 | — | — | US | disclosed |
| EP-1478613-A2 | SUBSTITUTED 10-ARYL-11H-BENZO[B]FLUORENES AND 7-ARYL-5,6-DIHYDRO-BENZ[A]ANTHRACENES FOR SELECTIVE EFFECTS ON ESTROGEN RECEPTORS | Akzo Nobel N.V. (NL) | 2004-11-24 | — | — | EP | disclosed |
| US-6756375-B2 | ESTROGEN RECEPTOR MODULATION; HORMONE REPLACEMENT THERAPY | AKZO NOBEL N.V. (NL) | 2004-06-29 | — | — | US | disclosed |
| US-20040059004-A1 | 10-ARYL-11H-BENZO[B]FLUORENE DERIVATIVES AND ANALOGS FOR MEDICINAL USE | MERCK SHARP & DOHME B.V. (NL) | 2004-03-25 | — | — | US | disclosed |
| US-6696573-B1 | SYNTHESIS OF SUCH AS 2-(N-(2-(9H-CARBAZOL-2-YLOXY)ETHYL))-AMINO-1-((3 -METHYLSULFONYLAMINO)PHENYL)ETHANOL WITH ENHANCED OPTICAL PURITY | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2004-02-24 | — | — | US | disclosed |
| CN-1138793-C | Process for producing polyethylene | �Ϻ���ͨ��ѧ | 2004-02-18 | — | — | CN | disclosed |
| US-20030225289-A1 | Process for the preparation of tricyclic amino alcohol derivatives | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2003-12-04 | — | — | US | disclosed |
| WO-2003070675-A2 | SUBSTITUTED 10-ARYL-11H-BENZO[B]FLUORENES AND 7-ARYL-5,6-DIHYDRO-BENZO[A]ANTHRACENES FOR SELECTIVE EFFECTS ON ESTROGEN RECEPTORS | AKZO NOBEL N.V. (NL) | 2003-08-28 | — | — | WO | disclosed |
| EP-1313700-A1 | 10-ARYL-11H-BENZO[B]FLUORENE DERIVATIVES AND ANALOGS AS ESTROGENIC COMPOUNDS | Akzo Nobel N.V. (NL) | 2003-05-28 | — | — | EP | disclosed |
| EP-1209150-A1 | PROCESSES FOR THE PREPARATION OF TRICYCLIC AMINO ALCOHOL DERIVATIVES | Asahi Kasei Kabushiki Kaisha (JP) | 2002-05-29 | — | — | EP | disclosed |
| WO-2002016316-A1 | 10-ARYL-11-HBENZO [b]FLUORENE DERIVATIVES AND ANALOGS FOR MEDICINAL USE | AKZO NOBEL N.V. (NL) | 2002-02-28 | — | — | WO | disclosed |
| CN-1332753-A | Process for producing polyethylene | EASTMAN CHEM CO (US) | 2002-01-23 | — | — | CN | disclosed |
| US-4005156-A | Novel flame retardant compositions of matter | UNIVERSAL OIL PRODUCTS COMPANY (US) | 1977-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159405-A1 | Substituted 10-aryl-11h-benzo[b]fluourenes and 7-aryl-5, 6-dihydro-benzo[a]anthracenes for selective effects on estrogen receptors | ESR1, ESR2, ESRRA | MEN1 3091/4885THRB 262/4885RECQL 1850/4885 |
| US-20030225289-A1 | Process for the preparation of tricyclic amino alcohol derivatives | ADH1A, ADH1C, OXER1 | MEN1 3399/4885THRB 865/4885RECQL 4648/4885 |
| US-20040059004-A1 | 10-ARYL-11H-BENZO[B]FLUORENE DERIVATIVES AND ANALOGS FOR MEDICINAL USE | ESRRA, ESR2, ESRRB | MEN1 3016/4885THRB 167/4885RECQL 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.