SCHEMBL5030756

SCHEMBL5030756

O=C(O)c1cc2ccccc2c(=O)n1O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.61
LDHA P00338 3/20 0.49
ALDH1A1 P00352 2/20 0.48
KDM4E B2RXH2 2/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CYP1A2 P05177 1/20 0.48
GLA P06280 1/20 0.48
HPGD P15428 1/20 0.48
CYP2C19 P33261 1/20 0.48
HSD17B10 Q99714 1/20 0.48
FDPS P14324 1/20 0.47
MCL1 Q07820 1/20 0.46
TSHR P16473 1/20 0.45
CCR2 P41597 1/20 0.41
PLA2G10 O15496 1/20 0.41
NR4A1 P22736 1/20 0.40
NR4A2 P43354 1/20 0.40
NR4A3 Q92570 1/20 0.40
CA12 O43570 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16622498 0.83 DAO (0.41) DAOALDH1A1KDM4EMEN1KMT2A
SCHEMBL1202364 0.82 KMT2A (0.48) DAOLDHAALDH1A1KDM4EMEN1
SCHEMBL31371682 0.81 MCL1 (0.62) DAOALDH1A1KDM4EMEN1KMT2A
SCHEMBL3282509 0.81 MCL1 (0.62) DAOALDH1A1KDM4EMEN1KMT2A
SCHEMBL14402322 0.76 ALDH1A1 (0.45) ALDH1A1KDM4EHPGDHSD17B10TSHR
SCHEMBL7561 0.76 DAO (1.00) DAOLDHAALDH1A1CYP1A2FDPS
SCHEMBL1436331 0.74 ERCC1 (0.44) ALDH1A1KDM4EKMT2AHPGDHSD17B10
SCHEMBL13074842 0.74 ERCC1 (0.41) ALDH1A1KDM4EMEN1KMT2ACYP1A2
SCHEMBL13074731 0.74 KDM4E (0.49) ALDH1A1KDM4EKMT2ACYP1A2HPGD
SCHEMBL32673552 0.73 ALDH1A1 (0.54) ALDH1A1KDM4EMEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2511266-B1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES UNIV CALIFORNIA (US) 2019-09-04 EP disclosed
US-9556122-B2 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-01-31 US disclosed
US-9556122-B2 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-01-31 US disclosed
US-20140039169-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2014-02-06 US disclosed
US-20140039169-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2014-02-06 US disclosed
US-8557601-B2 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-10-15 US disclosed
US-8557601-B2 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-10-15 US disclosed
EP-2511266-A1 Luminescent 1-Hydroxy-2-Pyridinone Chelates of Lanthanides The Regents of The University of California (US) 2012-10-17 EP disclosed
US-20100015725-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-01-21 US disclosed
US-20100015725-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-01-21 US disclosed
WO-2007121453-A3 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS UNIV CALIFORNIA (US) 2008-07-31 WO disclosed
WO-2008008797-A2 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-01-17 WO disclosed
WO-2007121453-A2 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-10-25 WO disclosed
WO-2007121453-A2 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-10-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140039169-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES PLPBP, HPD, LASP1 DAO 3348/4885LDHA 90/4885ALDH1A1 411/4885
US-20100015725-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES PLPBP, HPD, LASP1 DAO 3348/4885LDHA 90/4885ALDH1A1 411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.