Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 8/20 | 0.44 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | PEPD | P12955 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029408 | 0.85 | SORT1 (0.40) | NR3C2GRIN3BGRIN1GRIN2CDHODH | |
| SCHEMBL30948751 | 0.79 | NR3C2 (0.47) | NR3C2DHODHHDAC6 | |
| SCHEMBL11710154 | 0.70 | NOS3 (0.39) | — | |
| SCHEMBL2787917 | 0.67 | PEPD (0.39) | NR3C2KIF11PEPDALDH1A1 | |
| SCHEMBL6907368 | 0.66 | NR3C2 (0.36) | NR3C2KIF11PEPDALDH1A1 | |
| SCHEMBL30875900 | 0.66 | NR3C2 (0.67) | NR3C2KIF11SORT1ALDH1A1 | |
| SCHEMBL30595621 | 0.66 | SMARCA2 (0.64) | NR3C2KIF11HDAC6 | |
| SCHEMBL15992647 | 0.66 | SMARCA2 (0.64) | NR3C2KIF11HDAC6 | |
| SCHEMBL5029590 | 0.66 | NR3C2 (0.67) | NR3C2KIF11SORT1ALDH1A1 | |
| SCHEMBL24598127 | 0.65 | SMN1; SMN2 (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | claimed |