SCHEMBL5031707

SCHEMBL5031707

CCN(CC)/C(Cc1ccccc1)=N/C(=S)NC

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
MGLL Q99685 1/20 0.44
GLA P06280 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39
LMNA P02545 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
CHRM2 P08172 1/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
CHRM1 P11229 1/20 0.38
DRD1 P21728 1/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
ADRA1A P35348 1/20 0.38
OPRM1 P35372 1/20 0.38
DRD3 P35462 1/20 0.38
SLC6A3 Q01959 1/20 0.38
KCNH2 Q12809 1/20 0.38
MAPT P10636 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5027083 0.85 MAPK1 (0.47) ALDH1A1MGLLLMNAL3MBTL1MAPT
SCHEMBL4398352 0.84 ALDH1A1 (0.43) ALDH1A1MGLLLMNAL3MBTL1MAPT
SCHEMBL4398354 0.84 ALDH1A1 (0.43) ALDH1A1MGLLLMNAL3MBTL1MAPT
SCHEMBL5028982 0.80 ALDH1A1 (0.47) ALDH1A1LMNAL3MBTL1POLBTDP1
SCHEMBL5028967 0.79 ALDH1A1 (0.49) ALDH1A1LMNAL3MBTL1MAPTPOLB
SCHEMBL4393306 0.76 GLA (0.50) ALDH1A1MGLLGLACACNA1BAPBA1
SCHEMBL8325341 0.68 ALDH1A1 (0.45) ALDH1A1LMNAMAPTPOLBKMT2A
SCHEMBL10866850 0.67 ALDH1A1 (0.66) ALDH1A1LMNAL3MBTL1MAPTPOLB
SCHEMBL2727273 0.66 LMNA (0.50) ALDH1A1MGLLLMNACHRM2HTR1A
SCHEMBL4398332 0.66 EHMT2 (0.36) ALDH1A1MGLLLMNAHTR1AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2007393-A2 THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (US) 2008-12-31 EP disclosed
WO-2007118149-A2 THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL LOLLEGE (US) 2007-10-18 WO disclosed