Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032631 | 0.93 | CYP3A4 (0.37) | CRHBPCRHR2CYP3A4FLT1FLT4 | |
| SCHEMBL5035010 | 0.93 | CYP3A4 (0.39) | CRHBPCRHR2CYP3A4FLT1FLT4 | |
| SCHEMBL5036077 | 0.91 | CYP3A4 (0.42) | CYP3A4HRH4CYP11B1CYP11B2RAD52 | |
| SCHEMBL5035949 | 0.90 | CYP3A4 (0.42) | CYP3A4FLT1FLT4KDRTSHR | |
| SCHEMBL5036040 | 0.88 | LMNA (0.42) | CYP3A4HSP90AA1MEN1KMT2A | |
| SCHEMBL14190166 | 0.87 | CYP3A4 (0.37) | CRHBPCRHR2CYP3A4FLT1FLT4 | |
| SCHEMBL5039107 | 0.87 | CYP3A4 (0.38) | CYP3A4FLT1FLT4KDRTSHR | |
| SCHEMBL5041489 | 0.87 | CYP3A4 (0.41) | CRHBPCRHR2CYP3A4TSHRCYP11B1 | |
| SCHEMBL5035948 | 0.85 | CYP3A4 (0.40) | CRHBPCRHR2CYP3A4FLT1FLT4 | |
| SCHEMBL5035235 | 0.84 | CYP3A4 (0.45) | CYP3A4CYP11B1CYP11B2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |