Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190180 | 0.88 | CDK8 (0.44) | LMNAMAPK1CDK8CLK4KMT2A | |
| SCHEMBL5032631 | 0.88 | CYP3A4 (0.37) | LMNAMAPK1KMT2AMAPTHSP90AA1 | |
| SCHEMBL5032562 | 0.88 | CRHBP (0.36) | KMT2AHSP90AA1MEN1CYP3A4 | |
| SCHEMBL5039076 | 0.88 | CYP3A4 (0.39) | MAPK1KMT2AHSP90AA1NPC1GAA | |
| SCHEMBL5034877 | 0.85 | CYP3A4 (0.44) | KMT2AMAPTNPC1MEN1CYP3A4 | |
| SCHEMBL5036077 | 0.85 | CYP3A4 (0.42) | KMT2AMAPTNPC1ALDH1A1MEN1 | |
| SCHEMBL5034908 | 0.83 | CYP3A4 (0.43) | KMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL5041488 | 0.83 | CYP3A4 (0.42) | KMT2AMEN1CYP3A4 | |
| SCHEMBL5035949 | 0.83 | CYP3A4 (0.42) | LMNAKMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL5035010 | 0.83 | CYP3A4 (0.39) | MAPTNPC1ALDH1A1GAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |