Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039367 | 0.91 | KDM4E (0.41) | KDM4EALDH1A1HTTNPSR1MAPT | |
| SCHEMBL5036077 | 0.91 | CYP3A4 (0.42) | KDM4EALDH1A1HTTNPSR1MAPT | |
| SCHEMBL5036024 | 0.85 | ALDH1A1 (0.37) | KDM4EALDH1A1HTTNPSR1MAPT | |
| SCHEMBL5035132 | 0.85 | KDM4E (0.45) | KDM4EALDH1A1HTTNPSR1MAPT | |
| SCHEMBL5034877 | 0.83 | CYP3A4 (0.44) | KDM4EHTTMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5039076 | 0.83 | CYP3A4 (0.39) | KDM4ENPSR1RAB9ASMN1; SMN2CYP11B1 | |
| SCHEMBL5032562 | 0.82 | CRHBP (0.36) | CYP11B1MEN1KMT2ARAD52HRH4 | |
| SCHEMBL5035235 | 0.82 | CYP3A4 (0.45) | ALDH1A1HTTNPSR1MAPTRAB9A | |
| SCHEMBL5034908 | 0.82 | CYP3A4 (0.43) | HTTMAPTSMN1; SMN2CYP11B1MEN1 | |
| SCHEMBL5041488 | 0.81 | CYP3A4 (0.42) | HTTSMN1; SMN2CYP11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |