Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | CFD | P00746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL333955 | 0.76 | HSD17B10 (0.39) | KDM4ERAB9AMAPTTP53LMNA | |
| SCHEMBL5812651 | 0.76 | RAB9A (0.56) | SMN1; SMN2NPC1RAB9ATP53HPGD | |
| SCHEMBL5033380 | 0.73 | CFD (0.49) | GSK3BCFDKDM4ESMN1; SMN2EPHX1 | |
| SCHEMBL714625 | 0.73 | EPHX1 (0.77) | GSK3BCFDKDM4ESMN1; SMN2EPHX1 | |
| SCHEMBL2831462 | 0.72 | NPC1 (0.77) | CFDKDM4ESMN1; SMN2EPHX1NPC1 | |
| SCHEMBL1395125 | 0.71 | GSK3B (0.49) | GSK3BCFDKDM4ESMN1; SMN2EPHX1 | |
| SCHEMBL1131124 | 0.71 | RIPK1 (0.56) | GSK3BSMN1; SMN2RAB9ALMNA | |
| SCHEMBL20804368 | 0.71 | NPC1 (0.65) | GSK3BCFDKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL4307478 | 0.70 | GSK3B (1.00) | GSK3BKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL7519969 | 0.70 | GSK3B (0.50) | GSK3BCFDKDM4ESMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919465-A2 | GSK-3 INHIBITORS | Neuropharma S.A. (ES) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007017145-A2 | GSK-3 INHIBITORS | NEUROPHARMA, S.A. (ES) | 2007-02-15 | — | — | WO | disclosed |