Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.64 |
| ▸ | CCKBR | P32239 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14122143 | 0.88 | PDE5A (0.67) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL4047718 | 0.88 | CCKBR (0.71) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL14122016 | 0.88 | PDE5A (0.67) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL14121883 | 0.88 | PDE5A (0.67) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL14121446 | 0.88 | PDE5A (0.67) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL13402901 | 0.84 | CCKBR (0.80) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL13402856 | 0.84 | CCKBR (0.80) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL13402897 | 0.84 | CCKBR (0.80) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL3482943 | 0.84 | CCKBR (0.80) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL8167872 | 0.84 | CCKBR (0.80) | PDE5ACCKBRKDM4EHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114017-A1 | Novel Indolopyridines, Benzofuranopyridines and Benzothienopyridines | 4SC AG (DE) | 2008-05-15 | — | — | US | disclosed |
| EP-1844046-A1 | NOVEL INDOLOPYRIDINES, BENZOFURANOPYRIDINES AND BENZOTHIENOPYRIDINES | Nycomed GmbH (DE) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006079645-A1 | NOVEL INDOLOPYRIDINES , BENZOFURANOPYRIDINES AND BENZOTHIENOPYRIDINES | NYCOMED GMBH (DE) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114017-A1 | Novel Indolopyridines, Benzofuranopyridines and Benzothienopyridines | BAX, API5, AIFM1 | PDE5A 2323/4885CCKBR 1839/4885KDM4E 2572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.